Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers
نویسندگان
چکیده
منابع مشابه
Verbascoside Alleviates Pneumococcal Pneumonia by Reducing Pneumolysin Oligomers.
Pneumolysin (PLY), an essential virulence factor of Streptococcus pneumoniae (pneumococcus), can penetrate the physical defenses of the host and possesses inflammatory properties. The vital role PLY plays in pneumococcus pathogenesis makes this virulence factor one of the most promising targets for the treatment of pneumococcal infection. Verbascoside (VBS) is an agent that does not exhibit bac...
متن کاملDiagnosis of pneumococcal pneumonia by enzyme-linked immunosorbent assay of antibodies to pneumococcal hemolysin (pneumolysin).
An enzyme-linked immunosorbent assay (ELISA) with a highly purified pneumolysin as the antigen was evaluated for serological diagnosis of pneumococcal pneumonia. One hundred four healthy controls were tested, and the specificity of the test was set to 95%. In samples from patients with bacteremic pneumococcal pneumonia, 82% (18 of 22) were positive, i.e., at least one serum sample had a titer a...
متن کاملProtection against pneumococcal pneumonia in mice by monoclonal antibodies to pneumolysin.
Pneumolysin (PLY) is an important virulence factor of Streptococcus pneumoniae. We examined the ability of three murine monoclonal antibodies (MAbs) to PLY (PLY-4, PLY-5, and PLY-7) to affect the course of pneumococcal pneumonia in mice. The intravenous administration of antibodies PLY-4 and PLY-7 protected the mice from the lethal effect of the purified toxin. Mice treated with PLY-4 before in...
متن کاملScreening of Pneumococcal Pneumonia by Amplification of Pneumolysin Gene in Children Visiting Hospitals in Lahore, Pakistan
OBJECTIVE Streptococcus pneumoniae is a common worldwide potential pathogen causing pneumonia among children and the detection of pneumococcal infections by conventional culturing techniques is cumbersome. The present study describes a comparative analysis of sensitive nested-PCR and bacterial culture in pediatric patients with clinical and radiological indication of S. pneumoniae infection. ...
متن کاملIncomplete pneumolysin oligomers form membrane pores
Pneumolysin is a member of the cholesterol-dependent cytolysin (CDC) family of pore-forming proteins that are produced as water-soluble monomers or dimers, bind to target membranes and oligomerize into large ring-shaped assemblies comprising approximately 40 subunits and approximately 30 nm across. This pre-pore assembly then refolds to punch a large hole in the lipid bilayer. However, in addit...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2015
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.115.100610